Shear-Thinning Rheology of the Abuse-Deterrent Dosage Form Extracts

Effect of abuse-deterrent formulation of OxyContin.

To the Editor: In August 2010, an abuse-deterrent formulation of the widely abused prescription opioid OxyContin was introduced. The intent was to make OxyContin more difficult to solubilize or crush, thus discouraging abuse through injection and inhalation. We examined the effect of the abuse-deterrent formulation on the abuse of OxyContin and other opioids. Data were collected quarterly from ...

Abuse-Deterrent Opioids — Evaluation and Labeling

Correlation between Powder Rheology Data and Processability in Solid Dosage Form Manufacturing

from powder characterisation and how the data correlates to process performance and drug product quality in solid dosage form develop ment projects. Data from two development studies will be shown. The development and manufacturing of solid dosage forms relies heavily on powder material. API and tablet excipients are most often handled as a granular material. The powders are mixed and compresse...

Contact-line motion of shear-thinning liquids

It is demonstrated that, for the slow advance of a viscous liquid onto a previously dry substrate, the well-known moving contact line paradox is alleviated for liquids exhibiting power-law shear-thinning behavior. In contrast to previous models that allow contact-line motion, it is no longer necessary to abandon the no-slip condition at the substrate in the vicinity of’the contact point. While ...

Turbulent pipe flow of shear-thinning fluids

Direct numerical simulation of the weakly turbulent flow of non-Newtonian fluids is undertaken for two different generalised Newtonian rheology models using a spectral element-Fourier method. Results for a power law (shear-thinning) rheology agree well with experimentally determined logarithmic layer correlations and with other previously published experimental work. As the flow index becomes s...